Neuroprotective Protein ADNP-Dependent Histone Remodeling Complex Promotes T Helper 2 Immune Cell Differentiation

To better understand transcriptional regulation of T helper 2 cell differentiation, researchers performed CRISPR-Cas9 screens targeting 1,131 transcription factors..They discovered that activity-dependent neuroprotector homeobox protein was indispensable for immune reactions to allergen.