Circular RNAs Drive Oncogenic Chromosomal Translocations within the MLL Recombinome in Leukemia

Researchers showed that circular RNAs (circRNAs)—a family of covalently closed, alternatively spliced RNA molecules—were enriched within the mixed lineage leukemia (MLL) recombinome and could bind DNA, forming circRNA:DNA hybrids at their cognate loci.