Basal Type I Interferon Signaling Has Only Modest Effects on Neonatal and Juvenile Hematopoiesis

Investigators characterized hematopoiesis at several different stages of blood formation, from HSCs to mature blood cells, and found that loss of the IFN-1 receptor led to depletion of several phenotypic HSC and multipotent progenitors subpopulations in neonatal and juvenile mice.