A Critical Role of RUNX1 in Governing Megakaryocyte-Primed Hematopoietic Stem Cell Differentiation

By using Runx1F/FMx1-Cre mouse model, scientists discovered that the megakaryocyte (MK)-HSC to MK direct differentiation could occur within 1 cell division, and RUNX1 was an important regulator in the process.