An Inducible hACE2 Transgenic Mouse Model Recapitulates SARS-CoV-2 Infection and Pathogenesis In Vivo

Scientists reported an inducible, transgenic human angiotensin–converting enzyme II (hACE2) mouse line and showcase three examples for specifically expressing hACE2 in three different lung epithelial cells, including AT2 cells, club cells, and ciliated cells.