HDGF Promotes Gefitinib Resistance by Activating the PI3K/AKT and MEK/ERK Signaling Pathways in Non-small Cell Lung Cancer

Researchers explored the role of hepatoma-derived growth factor (HDGF) in gefitinib resistance in NSCLC and discovered the underlying mechanisms. Stable HDGF knockout or overexpression cell lines were generated to perform experiments in vitro and in vivo.