Targeting Transglutaminase 2 Mediated Exostosin Glycosyltransferase 1 Signaling in Liver Cancer Stem Cells with Acyclic Retinoid

Investigators examined the subcellular location-dependent effects of acyclic retinoid on transglutaminase 2 activity at a structural level and characterized the functional role of TG2 and its downstream molecular mechanism in the selective depletion of liver CSCs.