Cardiomyocyte Peroxisome Proliferator-Activated Receptor α Prevents Septic Cardiomyopathy via Improving Mitochondrial Function

Peroxisome proliferator-activated receptor (Ppara) disruption in cardiomyocytes augmented mitochondrial dysfunction, as revealed by damaged mitochondria, lowered ATP contents, decreased mitochondrial complex activities, and increased DRP1/MFN1 protein levels.