Vascular Protection Afforded by Zinc Supplementation in Human Coronary Artery Smooth Muscle Cells Mediated by NRF2 Signaling Under Hypoxia/Reoxygenation

Scientists compared the effects of Zinc chelation or supplementation on total intracellular Zinc content, antioxidant NRF2 targeted gene transcription, and hypoxia/reoxygenation-induced reactive oxygen species generation in human coronary artery smooth muscle cells pre-adapted to hyperoxia or normoxia.