Attenuation of OX40 Signaling Suppression by Age Disrupts Peripheral Deletion of CD4⁺ T Cells Specific for the Epidermal Autoantigen Desmoglein 3

Researchers used CD4+ T cells expressing a transgenic T cell receptor specific for desmoglein 3, which is the target antigen of the autoimmune bullous disease pemphigus vulgaris, to examine how peripheral immunological tolerance against pathogenic autoreactive CD4+ T cells changed with age.