BCR-ABL Promotes Hematopoietic Stem and Progenitor Cell Formation in Embryonic Stem Cells

Scientists showed in a unique site-directed knock-in embryonic stem cells model, that BCR-ABL expression tightly regulated by doxycycline controls the formation and the maintenance of immature hematopoietic progenitors. Interestingly, these progenitors can be expanded in vitro for several passages in the presence of dox.