Immune Escape After Allogeneic Hematopoietic Cell Transplantation in Pediatric Acute Myeloid Leukemia

To identify pressures imposed by allogeneic hematopoietic cell transplantation on AML cells that escaped the graft-versus-leukemia effect, investigators evaluated immune signatures at diagnosis and post-transplant relapse in bone marrow samples from four pediatric patients using a multimodal single-cell proteogenomic approach.