The Contribution of Inflammatory Astrocytes to BBB Impairments in a Brain-Chip Model of Parkinson’s Disease

Investigators focused on an unexplored area of Parkinson’s disease pathogenesis by characterizing the interplay between astrocytes, inflammation, and blood-brain barrier (BBB) integrity, and by combining patient-derived induced pluripotent stem cells with microfluidic technologies to generate a 3D human BBB chip.