USP12 Promotes Nonsmall Cell Lung Cancer Progression Through Deubiquitinating and Stabilizing RRM2

Researchers showed that ubiquitin-specific peptidase 12 (USP12) directly interacted with and deubiquitinates RRM2 in NSCLC cells. Knockdown of USP12 causes DNA replication stress and retards tumor growth in vivo and in vitro.