Lipid Kinase PIP5Kα Contributes to Hippo Pathway Activation via Interaction with Merlin and by Mediating Plasma Membrane Targeting of LATS1

PIP5Kα, Merlin, or LATS1 knockout or knockdown cells and transfected cells with them were used. LATS1, YAP, and TAZ activities were measured using biochemical methods and PIP2 levels were evaluated using cell imaging.