Activated KRAS Reprograms Neural Progenitor Cells to Glioma Stem Cell-Like Phenotype

How neoplastic transformation occurs in normal neural projenitor cells (NPCs) and the role of the Ras/Raf/MAPK pathway in NPC transformation is unclear. Investigators generated NPCs from human embryonic stem cells carrying gene alterations in the Ras/Raf/MAPK pathway.