Orthotopic Model of Pancreatic Cancer Using CD34⁺ Humanized Mice and Generation of Tumor Organoids from Humanized Tumors

Researchers constructed an orthotopic xenograft model using CD34+ human hematopoietic stem cell–based humanized NOD scid gamma mouse mice injected with luciferase-expressing pancreatic cancer cell lines AsPC1 and BxPC3.