Hexokinase Dissociation from Mitochondria Promotes Oligomerization of VDAC That Facilitates NLRP3 Inflammasome Assembly and Activation

Researchers reported that multiple canonical activators of NLRP3 in mouse macrophages shared the ability to displace the glycolytic enzyme hexokinase 2 from the voltage-dependent anion channel (VDAC) on the outer membranes of mitochondria.