Hedgehog Signaling via Its Ligand DHH Acts as Cell Fate Determinant During Skeletal Muscle Regeneration

Using conditional mutagenesis and pharmacological Hedgehog (Hh) modulators in vivo and in vitro, investigators identified Desert Hh (DHH) as the key ligand that acted as a potent adipogenic brake by preventing the adipogenic differentiation of fibro/adipogenic progenitors.