Loss of miR-144/451 Alleviates β-Thalassemia by Stimulating ULK1-Mediated Autophagy of Free α-Globin

Investigators showered that disruption of the bi-cistronic microRNA locus miR-144/451 alleviated β-thalassemia by reducing mTORC1 activity and stimulating ULK1-mediated autophagy of free α-globin through two mechanisms.