The Effect of Blocking Immune Checkpoints LAG-3 and PD-1 on Human Invariant Natural Killer T Cell Function

Investigators determined whether the blockade of programmed cell-death-1 (PD-1) and/or lymphocyte-activation-gene-3 (LAG-3) could enhance invariant Natural Killer T (iNKT) cell function. Utilizing peripheral blood mononuclear cells from healthy donors, they assessed the LAG-3 and PD-1 expression on iNKT cells.