Collagen VI Deposition Mediates Stromal T Cell Trapping through Inhibition of T Cell Motility in the Prostate Tumor Microenvironment

Investigators showed that Collagen VI (Col VI) deposition correlated with stromal T cell density in human prostate cancer specimens. Motility of CD4+ T cells was completely ablated on purified Col VI surfaces when compared with Fibronectin and Collagen I.