Mdm2/p53 Levels in Bone Marrow Mesenchymal Stromal Cells Are Essential for Maintaining the Hematopoietic Niche in Response to DNA Damage

To advance the understanding of physiological functions of p53 and Mdm2 in BM-MSCs, the authors developed traceable conditional mouse models targeting Mdm2 and/or Trp53 in vivo.