Mesenchymal Stem Cells Ameliorate Chronic GVHD by Boosting Thymic Regeneration in a CCR9-Dependent Manner in Mice

Investigators showed in a murine graft-versus-host disease model that MSCs promoted the quantity and maturity of thymic epithelial cells (TECs) as well as elevated the proportion of Aire+ medullary TECs, improving both CD4+CD8+ double-positive thymocytes and thymic Tregs, balancing CD4/CD8 ratio in blood.