Bioactive Cell Niche Mediating Uniform Thermal Stimulus for BMSC Neural Differentiation through TRPV1 Channel Activation

The authors established a near-infrared light initiated photothermal stimulus platform, with full bioactivity and high thermal manipulation efficiency. They proved that the thermal activation, from matrix to cells, triggered TRPV1 ion channel opening and Ca2+ influx, which finally promoted neural differentiation of bone marrow MSCs.