Schizophrenia-Associated NRXN1 Deletions Induce Developmental-Timing- and Cell-Type-Specific Vulnerabilities in Human Brain Organoids

Researchers leveraged human pluripotent stem cell-derived forebrain organoid models carrying NRXN1 heterozygous deletions in isogenic and schizophrenia patient genetic backgrounds and conducted single-cell transcriptomic analysis over the course of brain organoid development from 3 weeks to 3.5 months.