Discovery of an OTUD3 Inhibitor for the Treatment of Non-small Cell Lung Cancer

Scientists reported a small-molecule inhibitor of OTUD3 (OTUDin3) by computer-aided virtual screening and biological experimental verification. OTUDin3 exhibited pronounced antiproliferative and proapoptotic effects by inhibiting deubiquitinating activity of OTUD3 in NSCLC cell lines.