Trans-Golgi Protein TVP23B Regulates Host-Microbe Interactions via Paneth Cell Homeostasis and Goblet Cell Glycosylation

Using a forward genetic screen, scientists found a mutation in Tvp23b, which conferred susceptibility to chemically induced and infectious colitis. Trans-Golgi apparatus membrane protein TVP23 homolog B is a transmembrane protein conserved from yeast to humans.