N4-Acetylcytidine Drives Glycolysis Addiction in Gastric Cancer via NAT10/SEPT9/HIF-1α Positive Feedback Loop

Researchers revealed that N4-acetylcytidine, a newly identified mRNA modification, enhanced hypoxia tolerance in gastric cancer cells by promoting glycolysis addiction. Specifically, acetyltransferase NAT10 transcription was regulated by HIF-1α, a key transcription factor of the cellular response to hypoxia.