Exosome-Delivered miR-153 From Trichinella spiralis Promotes Apoptosis of Intestinal Epithelial Cells by Downregulating Bcl2

Investigators elucidated the mechanisms by which miRNAs interact with intestinal epithelial cells. First, a miRNA library of Trichinella spiralis larvae was constructed; then, based on high-throughput miRNA sequencing results, miR-153 and its predicted target genes, namely, Agap2, Bcl2, and Pten, were selected for follow-up studies.