A Bispecific γδ T-Cell Engager Targeting EGFR Activates a Potent Vγ9Vδ2 T Cell–Mediated Immune Response against EGFR-Expressing Tumors

An EGFR-Vδ2 bispecific T-cell engager was generated and its capacity to activate Vγ9Vδ2 T cells and trigger antitumor activity were tested in multiple in vitro, in vivo, and ex vivo models.