Pharmacological GLUT3 Salvage Augments the Efficacy of Vitamin C-Induced TET2 Restoration in Acute Myeloid Leukemia

Scientists investigated the therapeutic value of glucose transporter 3 (GLUT3) restoration in AML. In vitro GLUT3 restoration was conducted with the transduction of GLUT3-overexpressing lentivirus or the pharmacological salvage with 5-aminoimidazole-4-carboxamide ribonucleotide treatment to OCI-AML3, a naturally GLUT3-deficient AML cell line.