AAV9-Tspyl2 Gene Therapy Retards Bleomycin-Induced Pulmonary Fibrosis by Modulating Downstream TGF-β Signaling in Mice

Investigators focused on cell division autoantigen-1, which was significantly decreased in human idiopathic pulmonary fibrosis (IPF), in a mouse model of bleomycin-induced PF, and in transforming growth factor (TGF-β)-challenged lung fibroblasts.