High Body Temperature Increases Gut Microbiota-Dependent Host Resistance to Influenza a Virus and SARS-CoV-2 Infection

Researchers demonstrated that exposure of mice to the high ambient temperature of 36 °C increased host resistance to viral pathogens including influenza virus and SARS-CoV-2. High heat-exposed mice increase basal body temperature over 38 °C to enabled more bile acids production in a gut microbiota-dependent manner.