UHRF1 Inhibition Epigenetically Reprograms Cancer Stem Cells to Suppress the Tumorigenic Phenotype of Hepatocellular Carcinoma

Hepatocyte-specific Uhrf1 knockout (Uhrf1HKO) strongly suppressed tumor initiation and CSC self-renewal in both diethylnitrosamine (DEN)/CCl4-induced and Myc-transgenic hepatocellular carcinoma mouse models.