Multivalent Tyrosine Kinase Inhibition Promotes T Cell Recruitment to Immune-Desert Gastric Cancers by Restricting Epithelial-Mesenchymal Transition via Tumor-Intrinsic IFN-γ Signaling

Bioinformatics, human and mouse gastric cancer (GC) cell lines, syngeneic murine gastric tumor model, and CTLA4 blockade were used to investigate the immunotherapeutic effects by restricting receptor tyrosine kinase signaling in immune desert type GC.