CXCR3 Expression in Regulatory T Cells Drives Interactions with Type I Dendritic Cells in Tumors to Restrict CD8⁺ T Cell Antitumor Immunity

Genetic ablation of CXCR3 in Treg cells disrupted dendritic cell (DC) 1-Treg cell interactions, and concomitantly increased DC-CD8+ T cell interactions.