NewslettersImmune Regulation NewsDysregulated IFN-γ Signals Promote Autoimmunity in STAT1 Gain-of-Function SyndromeBy Laurisa Dohm - July 7, 2023099To dissect underlying immune mechanisms, researchers generated Stat1 gain-of-function transgenic mice and confirmed the development of spontaneous humoral autoimmunity that recapitulated the human phenotype.[Science Translational Medicine]Abstract