RUNX1 Mutations Mitigate Quiescence To Promote Transformation of Hematopoietic Progenitors in Fanconi Anemia

In the context of the prototypical inherited bone marrow failure syndrome Fanconi anemia, researchers performed multiplexed gene editing of mutational hotspots in myelodysplastic syndrome-associated genes in human induced pluripotent stem cells followed by hematopoietic differentiation.