Dose-Dependent Expression of GFI1 Alters Metabolism in the Hematopoietic Progenitors and MLL::AF9-Induced Leukemic Cells

Using in vitro and ex vivo murine models of MLL::AF9-induced human AML and extra-cellular flux assays, investigators demonstrated that a lower growth factor independence 1 (GFI1) expression enhanced oxidative phosphorylation rate via upregulation of the FOXO1- MYC axis.