Acute Myeloid Leukemia Cells and MSC-Derived Exosomes Inhibiting Transformation in Myelodysplastic Syndrome

Scientists investigated the mechanism of exosomes’ role in the transformation of myelodysplastic syndrome (MDS) to AML. Exosomes in culture supernatants of MDS and AML cell lines were extracted by ultrafiltration and identified in three ways: morphology, size, and exosome protein surface markers.