Zeb1 and Tle3 Are Trans-Factors That Differentially Regulate the Expression of Myosin Heavy Chain-Embryonic and Skeletal Muscle Differentiation

Using C2C12 mouse myogenic cells, investigators found that Zinc-finger E-box binding homeobox 1 (Zeb1) and Transducin-like Enhancer of Split 3 (Tle3) proteins were crucial trans-factors that interacted and differentially regulated Myh3 expression.