Identification of a Novel Role for TL1A/DR3 Deficiency in Acute Respiratory Distress Syndrome That Exacerbates Alveolar Epithelial Disruption

Based on single-cell RNA and mRNA sequencing results, death receptor 3 (DR3) and its only known ligand tumor necrosis factor ligand-associated molecule 1A (TL1A) were significantly reduced in epithelium from an acute respiratory distress syndrome mice and cell models.