IL33-Mediated NPM1 Promotes Fibroblast-to-Myofibroblast Transition via ERK/AP-1 Signaling in Silica-Induced Pulmonary Fibrosis

Scientists demonstrated that the interleukin 33 (IL33) levels in the lung sections were significantly overexpressed after bleomycin and silica treatment. Chromatin immunoprecipitation assay, knockdown, and reverse experiments were performed in lung fibroblasts to prove gene interaction following exogenous IL33 treatment or cocultured with silica-treated lung epithelial cells.