Targeting Lymph Nodes for Systemic Immunosuppression Using Cell-Free-DNA-Scavenging And cGAS-Inhibiting Nanomedicine-In-Hydrogel for Rheumatoid Arthritis Immunotherapy

Upon subcutaneous injection, nanomedicine-in-hydrogel prolonged lymph node retention of the cGAS inhibitor RU.521 and cell free DNA (cfDNA)-scavenging cationic nanoparticles, which pharmacologically inhibit cGAS and scavenged cfDNA, respectively, to inhibit proinflammation.