Minichromosome Maintenance Protein 10 (McM10) Regulates Hematopoietic Stem Cell Emergence in the Zebrafish Embryo

Investigators used zebrafish to study the role of mcm10 during embryonic development and showed that mcm10 specifically regulates hematopoietic stem cell (HSC) emergence from the hemogenic endothelium. They demonstrated that mcm10-deficient embryos present an accumulation of DNA damage in nascent HSCs, inducing their apoptosis.