RGMb Impacts Partial Epithelial-Mesenchymal Transition and BMP2-Induced ID mRNA Expression Independent of PD-L2 in Nonsmall Cell Lung Cancer Cells

The functions of repulsive guidance molecule b (RGMb) and PD-L2 were examined using the two NSCLC cell lines HCC827 and A549. CRISPR/Cas9 was used to decrease the expression of RGMb and PD-L2, while lentiviral vectors were used to increase their expression.