Cancer Associated Fibroblasts Promote Cancer Stemness by Inducing Expression of the Chromatin Modifying Protein CBX4 in Squamous Cell Carcinoma

Investigators showed CBX4 was a critical regulator of the CSC phenotype in squamous cell carcinomas of the skin and hypopharynx. Moreover, Cancer associated fibroblasts could promote the expression of CBX4 in the CSC population through secretion of IL-6.