P62/SQSTM1 Binds With Claudin-2 To Target for Selective Autophagy in Stressed Intestinal Epithelium

Researchers examined if an interplay between autophagy and claudin-2 protects from colitis and associated epithelial injury. Crypt culture and intestinal epithelial cells are subjected to stress, including starvation or DSS, the chemical that induces colitis in-vivo.