A Genetic Method Specifically Delineates Th1-Type Treg Cells and Their Roles in Tumor Immunity

To determine the roles of T-bet-expressing Treg cells, scientists generated a mouse strain, called VeDTR, in which T-bet/Foxp3 double-positive cells were engineered to be specifically labeled and depleted by a combination of Cre- and Flp-recombinase-dependent gene expression control.